Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Hypoalphalipoproteinemia

MedGen UID:: 96877
•Concept ID:: C0473527
•: Disease or Syndrome

Synonyms:	alpha Lipoproteinemia, Hypo; HDL Cholesterol, Low Serum; Hypo alpha Lipoproteinemia; Hypo alpha Lipoproteinemias; Hypoalphalipoproteinemias; Lipoproteinemia, Hypo alpha; Lipoproteinemias, Hypo alpha
SNOMED CT:	Hypoalphalipoproteinemia (190785000)

Definition

A metabolic disorder characterized by deficiency of high density (alpha) lipoprotein in the blood. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHypoalphalipoproteinemia

Abnormal circulating metabolite concentration
- Abnormal circulating organic compound concentration
  - Abnormal circulating lipid concentration
    - Abnormal circulating cholesterol concentration
      - Abnormality of lipoprotein cholesterol concentration
        Hypolipoproteinemia
        Hypoalphalipoproteinemia
        Norum disease
        Tangier disease

Professional guidelines

PubMed

Very low HDL levels: clinical assessment and management.

Bonilha I, Luchiari B, Nadruz W, Sposito AC
Arch Endocrinol Metab 2023 Jan 18;67(1):3-18. doi: 10.20945/2359-3997000000585. PMID: 36651718 Free PMC Article

Low levels of high-density lipoprotein cholesterol (hypoalphalipoproteinemia). An approach to management.

Rosenson RS
Arch Intern Med 1993 Jul 12;153(13):1528-38. PMID: 8323418

Diagnosis and management of familial dyslipoproteinemia in children and adolescents.

Kwiterovich PO Jr
Pediatr Clin North Am 1990 Dec;37(6):1489-523. doi: 10.1016/s0031-3955(16)37021-3. PMID: 2259550

See all (8)

Recent clinical studies

Etiology

A machine learning approach to personalized predictors of dyslipidemia: a cohort study.

Gutiérrez-Esparza G, Pulido T, Martínez-García M, Ramírez-delReal T, Groves-Miralrio LE, Márquez-Murillo MF, Amezcua-Guerra LM, Vargas-Alarcón G, Hernández-Lemus E
Front Public Health 2023;11:1213926. Epub 2023 Sep 20 doi: 10.3389/fpubh.2023.1213926. PMID: 37799151 Free PMC Article

Very low HDL levels: clinical assessment and management.

Bonilha I, Luchiari B, Nadruz W, Sposito AC
Arch Endocrinol Metab 2023 Jan 18;67(1):3-18. doi: 10.20945/2359-3997000000585. PMID: 36651718 Free PMC Article

Whole-exome sequencing reveals damaging gene variants associated with hypoalphalipoproteinemia.

Dong W, Wong KHY, Liu Y, Levy-Sakin M, Hung WC, Li M, Li B, Jin SC, Choi J, Lopez-Giraldez F, Vaka D, Poon A, Chu C, Lao R, Balamir M, Movsesyan I, Malloy MJ, Zhao H, Kwok PY, Kane JP, Lifton RP, Pullinger CR
J Lipid Res 2022 Jun;63(6):100209. Epub 2022 Apr 20 doi: 10.1016/j.jlr.2022.100209. PMID: 35460704 Free PMC Article

Rare Diseases Related with Lipoprotein Metabolism.

Zhou H, Gong Y, Wu Q, Ye X, Yu B, Lu C, Jiang W, Ye J, Fu Z
Adv Exp Med Biol 2020;1276:171-188. doi: 10.1007/978-981-15-6082-8_11. PMID: 32705600

Familial hypoalphalipoproteinemias.

Frohlich J, Westerlund J, Sparks D, Pritchard PH
Clin Invest Med 1990 Aug;13(4):202-10. PMID: 2119926

See all (145)

Diagnosis

A machine learning approach to personalized predictors of dyslipidemia: a cohort study.

Progress in finding pathogenic DNA copy number variations in dyslipidemia.

Iacocca MA, Dron JS, Hegele RA
Curr Opin Lipidol 2019 Apr;30(2):63-70. doi: 10.1097/MOL.0000000000000581. PMID: 30664016

High density lipoprotein cholesterol and cancer: Marker or causative?

Pirro M, Ricciuti B, Rader DJ, Catapano AL, Sahebkar A, Banach M
Prog Lipid Res 2018 Jul;71:54-69. Epub 2018 Jun 4 doi: 10.1016/j.plipres.2018.06.001. PMID: 29879431

Analysis of familial hypoalphalipoproteinemia syndromes.

Frohlich J, Pritchard PH
Mol Cell Biochem 1992 Aug 18;113(2):141-9. doi: 10.1007/BF00231534. PMID: 1518505

Familial hypoalphalipoproteinemias.

Frohlich J, Westerlund J, Sparks D, Pritchard PH
Clin Invest Med 1990 Aug;13(4):202-10. PMID: 2119926

See all (44)

Therapy

A machine learning approach to personalized predictors of dyslipidemia: a cohort study.

Very low HDL levels: clinical assessment and management.

Bonilha I, Luchiari B, Nadruz W, Sposito AC
Arch Endocrinol Metab 2023 Jan 18;67(1):3-18. doi: 10.20945/2359-3997000000585. PMID: 36651718 Free PMC Article

Rare Diseases Related with Lipoprotein Metabolism.

Zhou H, Gong Y, Wu Q, Ye X, Yu B, Lu C, Jiang W, Ye J, Fu Z
Adv Exp Med Biol 2020;1276:171-188. doi: 10.1007/978-981-15-6082-8_11. PMID: 32705600

High density lipoprotein cholesterol and cancer: Marker or causative?

Pirro M, Ricciuti B, Rader DJ, Catapano AL, Sahebkar A, Banach M
Prog Lipid Res 2018 Jul;71:54-69. Epub 2018 Jun 4 doi: 10.1016/j.plipres.2018.06.001. PMID: 29879431

Familial hypoalphalipoproteinemia.

Glueck CJ, Melser MA, Borecki IB, Third JL, Rao DC, Laskarzewski PM
Adv Exp Med Biol 1986;201:83-92. doi: 10.1007/978-1-4684-1262-8_8. PMID: 3541525

See all (62)

Prognosis

A machine learning approach to personalized predictors of dyslipidemia: a cohort study.

Polygenic scores for dyslipidemia: the emerging genomic model of plasma lipoprotein trait inheritance.

Trinder M, Brunham LR
Curr Opin Lipidol 2021 Apr 1;32(2):103-111. doi: 10.1097/MOL.0000000000000737. PMID: 33395106

Hypoalphalipoproteinemia and BRAF(V600E) Mutation Are Major Predictors of Aortic Infiltration in the Erdheim-Chester Disease.

Cohen-Aubart F, Guerin M, Poupel L, Cluzel P, Saint-Charles F, Charlotte F, Arsafi Y, Emile JF, Frisdal E, Le Goff C, Donadieu J, Amoura Z, Lesnik P, Haroche J, Le Goff W
Arterioscler Thromb Vasc Biol 2018 Aug;38(8):1913-1925. doi: 10.1161/ATVBAHA.118.310803. PMID: 29930009

Low high-density lipoprotein cholesterol: current status and future strategies for management.

Singh V, Sharma R, Kumar A, Deedwania P
Vasc Health Risk Manag 2010 Oct 29;6:979-96. doi: 10.2147/VHRM.S5685. PMID: 21127701 Free PMC Article

Hypoalphalipoproteinemia (low high density lipoprotein) as a risk factor for coronary heart disease.

Vega GL, Grundy SM
Curr Opin Lipidol 1996 Aug;7(4):209-16. doi: 10.1097/00041433-199608000-00007. PMID: 8883496

See all (40)

Clinical prediction guides

A machine learning approach to personalized predictors of dyslipidemia: a cohort study.

Food Consumption and Metabolic Risks in Young University Students.

González-Torres S, González-Silva N, Pérez-Reyes Á, Anaya-Esparza LM, Sánchez-Enríquez S, Vargas-Becerra PN, Villagrán Z, García-García MR
Int J Environ Res Public Health 2021 Dec 31;19(1) doi: 10.3390/ijerph19010449. PMID: 35010709 Free PMC Article

Polygenic scores for dyslipidemia: the emerging genomic model of plasma lipoprotein trait inheritance.

Trinder M, Brunham LR
Curr Opin Lipidol 2021 Apr 1;32(2):103-111. doi: 10.1097/MOL.0000000000000737. PMID: 33395106

Atherogenic lipoproteins and diabetes mellitus.

Yoshino G, Hirano T, Kazumi T
J Diabetes Complications 2002 Jan-Feb;16(1):29-34. doi: 10.1016/s1056-8727(01)00199-4. PMID: 11872363

Familial hypo-alpha-lipoproteinemia.

Vergani C, Bettale G
Clin Chim Acta 1981 Jul 18;114(1):45-52. doi: 10.1016/0009-8981(81)90226-6. PMID: 7249374

See all (81)